Big Data

For Better Hearts


Key messages

WHAT is BigData@Heart?

BigData@Heart, is a European Innovative Medicines Initiative (IMI 2) funded project that aims to improve patient outcomes and reduce the societal burden of Acute Coronary Syndrome (ACS), Atrial Fibrillation (AF) and Heart Failure (HF). 

WHAT can you expect from BigData@Heart?

The expected impact of BigData@Heart includes: (1) definitions of disease and outcome that are universal, computable, and relevant for patients, clinicians, industry and regulators, (2) informatics platforms that link, visualise and harmonise data sources of varying types, completeness and structure; (3) data science techniques to develop new definitions of disease, identify new phenotypes, and construct personalized predictive models; and (4) guidelines that allow for cross-border usage of big data sources acknowledging ethical and legal constraints as well as data security. Practically, by accessing and harmonizing European wide data sets, the project´s ambition is to design prognosis algorithms that can predict the evolution of disease based on previous medical history, hospitalization and country-specific statistics. BigData@Heart has formed seven work packages that work interactively and transversally to create the research framework and the new methodologies will be tested in a set of six case studies.

WHY is BigData@Heart needed?

Despite remarkable progress in the management of ACS, AF and HF, their disease burden remains high. Improvement of related mortality & hospitalization rates, quality of life issues, health care expenditures and loss of productivity is crucial. Optimal management of these conditions is complicated by their complex etiologies, poor definition at the molecular level, and the added burden of co- / multi-morbidities. This leads to unpredictable and large variation in interindividual therapeutic response, heterogeneous prognoses, and treatment guidelines that are based on conventional risk factors & clinical markers of end-organ damage.  All of these  barriers pose major problems in the development and delivery of targeted CVD treatments.

WHICH data will be used in BigData@Heart?

The clinical researchers involved in BigData@Heart have been instrumental in shaping current treatment and management of ACS, AF, and HF. They are joining forces with leading European epidemiologists, big data scientists, cardiovascular medical professionals, pharmaceutical industry scientists, and patient organization representatives. Thanks to this public-private partnership approach, BigData@Heart has access to most of the relevant large-scale European CVD databases, ranging from electronic health records and disease registries through well-phenotyped clinical trials, omics-data, and large epidemiological cohorts, together covering >5 million cases of AF, HF and ACS and >16 million healthy individuals. BigData@Heat will be using innovative statistical, machine learning and data-mining methodologies.