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2022
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2021
Banerjee A, Pasea L, Chung SC, Direk K, Asselbergs F, Grobbee DE, Kotecha D, Anker SD, Dyszynski T, Tyl B, Denaxas S, Lumbers RT, Hemingway H. A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential. Eur J Heart Fail. 2021 Dec 30. doi: 10.1002/ejhf.2417. Epub ahead of print. PMID: 34969173.
Yuan S, Mason AM, Carter P, Vithayathil M, Kar S, Burgess S, Larsson SC. Selenium and cancer risk: Wide-angled Mendelian randomization analysis. Int J Cancer. 2022 Apr 1;150(7):1134-1140. doi: 10.1002/ijc.33902. Epub 2021 Dec 24. PMID: 34910310.
Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses. Lancet Diabetes Endocrinol. 2021 Dec;9(12):837-846. doi: 10.1016/S2213-8587(21)00263-1. Epub 2021 Oct 28. PMID: 34717822; PMCID: PMC8600124.
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Lim YMF, Molnar M, Vaartjes I, Savarese G, Eijkemans MJC, Uijl A, Vradi E, Suzart-Woischnik K, Brugts JJ, Brunner-La Rocca HP, Blanc-Guillemaud V, Couvelard F, Baudier C, Dyszynski T, Waechter S, Lund LH, Hoes AW, Tyl B, Asselbergs FW, Gerlinger C, Grobbee DE, Cronin M, Koudstaal S. Generalisability of Randomised Controlled Trials in Heart Failure with Reduced Ejection Fraction. Eur Heart J Qual Care Clin Outcomes. 2021 Oct 1:qcab070. doi: 10.1093/ehjqcco/qcab070. Epub ahead of print. PMID: 34596659.
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Higgins H, et al. Estimating the Population Benefits of Blood Pressure Lowering: A Wide‐Angled Mendelian Randomization Study in UK Biobank. Journal of the American Heart Association. 2021 Aug 28. doi: https://doi.org/10.1161/JAHA.121.021098
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O'Gallagher K, et al. Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19. BMC Cardiovascular Disorders. Jul 2021. DOI: https://doi.org/10.1186/s12872-021-02137-9
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Yuan S, Zheng JS, Mason AM, Burgess S, Larsson SC. Genetically predicted circulating vitamin C in relation to cardiovascular disease. Eur J Prev Cardiol. 2022 Jan 11;28(16):1829-1837. doi: 10.1093/eurjpc/zwab081. PMID: 34057996.
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med. 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102; PMCID: PMC8063383.
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Banerjee A, Chen S, Fatemifar G, Zeina M, Lumbers RT, Mielke J, Gill S, Kotecha D, Freitag DF, Denaxas S, Hemingway H. Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility. BMC Med. 2021 Apr 6;19(1):85. doi: 10.1186/s12916-021-01940-7. PMID: 33820530; PMCID: PMC8022365.
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Bunting K V, Stanbury M, Tica O, Kotecha D. Transforming clinical research by involving and empowering patients— the RATE-AF randomized trial. European Heart Journal. Feb 2021. DOI: https://doi.org/10.1093/eurheartj/ehab098
Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G, Ramond A, Sørensen E, Halldorsson GH, Paul DS, Burgdorf KS, Eggertsson HP, Howson JMM, Thørner LW, Kristmundsdottir S, et al. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Commun Biol. 2021 Feb 3;4(1):156. doi: 10.1038/s42003-020-01575-z. PMID: 33536631; PMCID: PMC7859200.
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Katsoulis M, Gomes M, Lai AG, Henry A, Denaxas S, Lagiou P, Nafilyan V, Humberstone B, Banerjee A, Hemingway H, Lumbers RT. Estimating the Effect of Reduced Attendance at Emergency Departments for Suspected Cardiac Conditions on Cardiac Mortality During the COVID-19 Pandemic. Circ Cardiovasc Qual Outcomes. 2021 Jan;14(1):e007085. doi: 10.1161/CIRCOUTCOMES.120.007085. Epub 2020 Dec 20. PMID: 33342219; PMCID: PMC7819531.
Carr E, Bendayan R, Bean D, Stammers M, Wang W, Zhang H, Searle T, Kraljevic Z, Shek A, Phan HTT, Muruet W, Gupta RK, Shinton AJ, Wyatt M, Shi T, Zhang X, Pickles A, Stahl D, Zakeri R, Noursadeghi M, O'Gallagher K, Rogers M, Folarin A, Karwath A, Wickstrøm KE, Köhn-Luque A, Slater L, Cardoso VR, Bourdeaux C, Holten AR, Ball S, McWilliams C, Roguski L, Borca F, Batchelor J, Amundsen EK, Wu X, Gkoutos GV, Sun J, Pinto A, Guthrie B, Breen C, Douiri A, Wu H, Curcin V, Teo JT, Shah AM, Dobson RJB. Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study. BMC Med. 2021 Jan 21;19(1):23. doi: 10.1186/s12916-020-01893-3. PMID: 33472631; PMCID: PMC7817348.
2020
Denaxas S, Shah AD, Mateen BA, Kuan V, Quint JK, Fitzpatrick N, Torralbo A, Fatemifar G, Hemingway H. A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems. JAMIA Open. 2020 Dec 5;3(4):545-556. doi: 10.1093/jamiaopen/ooaa047. PMID: 33619467; PMCID: PMC7717266.
Larsson SC, Mason AM, Kar S, Vithayathil M, Carter P, Baron JA, Michaëlsson K, Burgess S. Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study. BMC Med. 2020 Dec 2;18(1):370. doi: 10.1186/s12916-020-01839-9. PMID: 33261611; PMCID: PMC7709312.
Reyat JS, Chua W, Cardoso VR, Witten A, Kastner PM, Kabir SN, Sinner MF, Wesselink R, Holmes AP, Pavlovic D, Stoll M, Kääb S, Gkoutos GV, de Groot JR, Kirchhof P, Fabritz L. Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation. JCI Insight. 2020 Aug 20;5(16):e139179. doi: 10.1172/jci.insight.139179. PMID: 32814717; PMCID: PMC7455124.
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Gill D, Arvanitis M, Carter P, Hernández Cordero AI, Jo B, Karhunen V, Larsson SC, Li X, Lockhart SM, Mason A, Pashos E, Saha A, Tan VY, Zuber V, Bossé Y, Fahle S, Hao K, Jiang T, Joubert P, Lunt AC, Ouwehand WH, Roberts DJ, Timens W, van den Berge M, Watkins NA, Battle A, Butterworth AS, Danesh J, Di Angelantonio E, Engelhardt BE, Peters JE, Sin DD, Burgess S. ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study. R Soc Open Sci. 2020 Nov 18;7(11):200958. doi: 10.1098/rsos.200958. PMID: 33391794; PMCID: PMC7735342.
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Yuan S, Vithayathil M, Kar S, Carter P, Mason AM, Xie SH, Burgess S, Larsson SC. Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis. Allergy. 2021 May;76(5):1559-1562. doi: 10.1111/all.14616. Epub 2020 Oct 21. PMID: 33031565; PMCID: PMC8411419.
Titova OE, Michaëlsson K, Vithayathil M, Mason AM, Kar S, Burgess S, Larsson SC. Sleep duration and risk of overall and 22 site-specific cancers: A Mendelian randomization study. Int J Cancer. 2021 Feb 15;148(4):914-920. doi: 10.1002/ijc.33286. Epub 2020 Sep 14. PMID: 32895918; PMCID: PMC7821333.
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Schmidt AF, Finan C, Gordillo-Marañón M, Asselbergs FW, Freitag DF, Patel RS, Tyl B, Chopade S, Faraway R, Zwierzyna M, Hingorani AD. Genetic drug target validation using Mendelian randomisation. Nat Commun. 2020 Jun 26;11(1):3255. doi: 10.1038/s41467-020-16969-0. PMID: 32591531; PMCID: PMC7320010.
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Chen S, Banerjee A. Machine learning: a long way from implementation in cardiovascular disease. Heart (British Cardiac Society). 2020 Mar. doi: https://doi.org/10.1136/heartjnl-2019-316030.
Kalkman S, Mostert M, Udo-Beauvisage N, van Delden JJ, van Thiel GJ. Responsible data sharing in a big data-driven translational research platform: lessons learned. BMC Med Inform Decis Mak. 2019 Dec 30;19(1):283. doi: 10.1186/s12911-019-1001-y. PMID: 31888593; PMCID: PMC6936121.
Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB, Morley MP, Chaffin MD, Helgadottir A, Verweij N, Dehghan A, Almgren P, Andersson C, Aragam KG, Ärnlöv J, Backman JD, Biggs ML, Bloom HL, et al. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nat Commun. 2020 Jan 9;11(1):163. doi: 10.1038/s41467-019-13690-5. PMID: 31919418; PMCID: PMC6952380.
Bean DM, Teo J, Wu H, Oliveira R, Patel R, Bendayan R, Shah AM, Dobson RJB, Scott PA. Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data. PLoS One. 2019 Nov 25;14(11):e0225625. doi: 10.1371/journal.pone.0225625. PMID: 31765395; PMCID: PMC6876873.
Willems S, Meyer C, de Bono J, Brandes A, Eckardt L, Elvan A, van Gelder I, Goette A, Gulizia M, Haegeli L, Heidbuchel H, Haeusler KG, Kautzner J, Mont L, Ng GA, Szumowski L, Themistoclakis S, Wegscheider K, Kirchhof P. Cabins, castles, and constant hearts: rhythm control therapy in patients with atrial fibrillation. Eur Heart J. 2019 Dec 7;40(46):3793-3799c. doi: 10.1093/eurheartj/ehz782. PMID: 31755940; PMCID: PMC6898884.
Pasea L, Chung SC, Pujades-Rodriguez M, Shah AD, Alvarez-Madrazo S, Allan V, Teo JT, Bean D, Sofat R, Dobson R, Banerjee A, Patel RS, Timmis A, Denaxas S, Hemingway H. Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis. BMC Med. 2019 Nov 20;17(1):206. doi: 10.1186/s12916-019-1438-y. PMID: 31744503; PMCID: PMC6864929.
Kalkman S, van Delden J, Banerjee A, Tyl B, Mostert M, van Thiel G. Patients' and public views and attitudes towards the sharing of health data for research: a narrative review of the empirical evidence. J Med Ethics. 2022 Jan;48(1):3-13. doi: 10.1136/medethics-2019-105651. Epub 2019 Nov 12. PMID: 31719155; PMCID: PMC8717474.
Shah AD, Bailey E, Williams T, Denaxas S, Dobson R, Hemingway H. Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death. J Biomed Semantics. 2019 Nov 12;10(Suppl 1):20. doi: 10.1186/s13326-019-0214-4. PMID: 31711543; PMCID: PMC6849160.
Rahimi K, Kirchhof P. Self-palpation for detection of paroxysmal atrial fibrillation: Much noise with little signal. PLoS Med. 2020 Mar 31;17(3):e1003098. doi: 10.1371/journal.pmed.1003098. PMID: 32231353; PMCID: PMC7108683.
Littmann L. Letter by Littmann Regarding Article, "Association Between Use of Primary-Prevention Implantable Cardioverter-Defibrillators and Mortality in Patients With Heart Failure: A Prospective Propensity Score-Matched Analysis From the Swedish Heart Failure Registry". Circulation. 2020 Mar 17;141(11):e646-e647. doi: 10.1161/CIRCULATIONAHA.119.045175. Epub 2020 Mar 16. PMID: 32176545.
Stolfo D, Uijl A, Benson L, Schrage B, Fudim M, Asselbergs FW, Koudstaal S, Sinagra G, Dahlström U, Rosano G, Savarese G. Association between beta-blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score-matched analysis from the Swedish Heart Failure Registry. Eur J Heart Fail. 2020 Jan;22(1):103-112. doi: 10.1002/ejhf.1615. Epub 2019 Oct 23. Erratum in: Eur J Heart Fail. 2020 Jul;22(7):1287. PMID: 31478583.
2019
Kettunen J, Holmes MV, Allara E, Anufrieva O, Ohukainen P, Oliver-Williams C, Wang Q, Tillin T, Hughes AD, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT, Salomaa V, Järvelin MR, Perola M, Davey Smith G, Chaturvedi N, Danesh J, Di Angelantonio E, Butterworth AS, Ala-Korpela M. Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition. PLoS Biol. 2019 Dec 20;17(12):e3000572. doi: 10.1371/journal.pbio.3000572. Erratum in: PLoS Biol. 2020 Mar 6;18(3):e3000694. PMID: 31860674; PMCID: PMC6944381.
Bromage DI, Godec TR, Pujades-Rodriguez M, Gonzalez-Izquierdo A, Denaxas S, Hemingway H, Yellon DM. Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study. Cardiovasc Diabetol. 2019 Dec 9;18(1):168. doi: 10.1186/s12933-019-0972-4. PMID: 31815634; PMCID: PMC6900858.
Banerjee A, Allan V, Denaxas S, Shah A, Kotecha D, Lambiase PD, Joseph J, Lund LH, Hemingway H. Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis. Europace. 2019 Dec 1;21(12):1776-1784. doi: 10.1093/europace/euz220. Erratum in: Europace. 2019 Dec 1;21(12):1784. PMID: 31408153; PMCID: PMC6888023.
Denaxas S, Gonzalez-Izquierdo A, Direk K, Fitzpatrick NK, Fatemifar G, Banerjee A, Dobson RJB, Howe LJ, Kuan V, Lumbers RT, Pasea L, Patel RS, Shah AD, Hingorani AD, Sudlow C, Hemingway H. UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER. J Am Med Inform Assoc. 2019 Dec 1;26(12):1545-1559. doi: 10.1093/jamia/ocz105. PMID: 31329239; PMCID: PMC6857510.
Allara E, Morani G, Carter P, Gkatzionis A, Zuber V, Foley CN, Rees JMB, Mason AM, Bell S, Gill D, Lindström S, Butterworth AS, Di Angelantonio E, Peters J, Burgess S; INVENT consortium. Genetic Determinants of Lipids and Cardiovascular Disease Outcomes: A Wide-Angled Mendelian Randomization Investigation. Circ Genom Precis Med. 2019 Dec;12(12):e002711. doi: 10.1161/CIRCGEN.119.002711. Epub 2019 Nov 22. PMID: 31756303; PMCID: PMC6922071.
Li Q, Li X, Wang J, Liu H, Kwong JS, Chen H, Li L, Chung SC, Shah A, Chen Y, An Z, Sun X, Hemingway H, Tian H, Li S. Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements. BMJ Open. 2019 Aug 24;9(8):e026677. doi: 10.1136/bmjopen-2018-026677. PMID: 31446403; PMCID: PMC6720466.
Kalkman S, Mostert M, Gerlinger C, van Delden JJM, van Thiel GJMW. Responsible data sharing in international health research: a systematic review of principles and norms. BMC Med Ethics. 2019 Mar 28;20(1):21. doi: 10.1186/s12910-019-0359-9. PMID: 30922290; PMCID: PMC6437875.
Rienstra M, Kotecha D, van Veldhuisen DJ. Heart rate in patients with atrial fibrillation and heart failure with preserved ejection fraction: a prognosticator like in sinus rhythm? Eur J Heart Fail. 2019 Apr;21(4):480-481. doi: 10.1002/ejhf.1425. Epub 2019 Jan 30. PMID: 30698314.
Burns R, Pathak N, Campos-Matos I, Zenner D, Vittal Katikireddi S, Muzyamba MC, Miranda JJ, Gilbert R, Rutter H, Jones L, Williamson E, Hayward AC, Smeeth L, Abubakar I, Hemingway H, Aldridge RW. Million Migrants study of healthcare and mortality outcomes in non-EU migrants and refugees to England: Analysis protocol for a linked population-based cohort study of 1.5 million migrants. Wellcome Open Res. 2019 Jan 17;4:4. doi: 10.12688/wellcomeopenres.15007.1. PMID: 30801036; PMCID: PMC6381442.
Uijl A, Koudstaal S, Direk K, Denaxas S, Groenwold RHH, Banerjee A, Hoes AW, Hemingway H, Asselbergs FW. Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records. Eur J Heart Fail. 2019 Oct;21(10):1197-1206. doi: 10.1002/ejhf.1350. Epub 2019 Jan 7. PMID: 30618162; PMCID: PMC7074015.
2018
van der Laan SW, Harshfield EL, Hemerich D, Stacey D, Wood AM, Asselbergs FW. From lipid locus to drug target through human genomics. Cardiovasc Res. 2018 Jul 15;114(9):1258-1270. doi: 10.1093/cvr/cvy120. PMID: 29800275.
Hemerich D, van Setten J, Tragante V, Asselbergs FW. Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension. Front Cardiovasc Med. 2018 Apr 4;5:25. doi: 10.3389/fcvm.2018.00025. PMID: 29670885; PMCID: PMC5894467.
Gho JMIH, Schmidt AF, Pasea L, Koudstaal S, Pujades-Rodriguez M, Denaxas S, Shah AD, Patel RS, Gale CP, Hoes AW, Cleland JG, Hemingway H, Asselbergs FW. An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors. BMJ Open. 2018 Mar 3;8(3):e018331. doi: 10.1136/bmjopen-2017-018331. Erratum in: BMJ Open. 2018 Mar 22;8(3):e018331corr1. PMID: 29502083; PMCID: PMC5855447.
2017
Hemingway H, Asselbergs FW, Danesh J, Dobson R, Maniadakis N, Maggioni A, van Thiel GJM, Cronin M, Brobert G, Vardas P, Anker SD, Grobbee DE, Denaxas S; Innovative Medicines Initiative 2nd programme, Big Data for Better Outcomes, BigData@Heart Consortium of 20 academic and industry partners including ESC. Big data from electronic health records for early and late translational cardiovascular research: challenges and potential. Eur Heart J. 2018 Apr 21;39(16):1481-1495. doi: 10.1093/eurheartj/ehx487. PMID: 29370377; PMCID: PMC6019015.
Anker S, Asselbergs FW, Brobert G, Vardas P, Grobbee DE, Cronin M. Big Data in Cardiovascular Disease. Eur Heart J. 2017 Jun 21;38(24):1863-1865. doi: 10.1093/eurheartj/ehx283. PMID: 28863460.